HoneyLab undertake extensive Research & Development to develop novel and effective natural products. For some products, such as Melzest, Melzing and Melrest, this involves developing novel formulations of natural products for which strong science already exists. For others, such as Honevo, clinical studies are undertaken. In general, the clinical trials process is as follows:

Phase 1 studies – these “first time use by humans” studies are rarely required as most natural products have data to show that they are not dangerous.

Phase 2 studies – on most occasions, the first study is a phase 2 study – this is a smallish study of around 10-50 participants that is unlikely to prove that the product is safe and effective, but will give a signal as to whether the product may be effective and therefore if it is sensible to invest in a phase 3 study. Learnings from the phase 2 study also improve the quality of the phase 3 study, and the results of the phase 2 study are used to power the phase 3 study i.e. determine how many subjects are needed.

Phase 3 studies – these are large studies that provide definitive proof as to whether a product is safe and effective. 100-1,000 participants are usually needed, with the exact number being derived from the phase 2 study.

HoneyLab has undertaken the world’s largest programme of clinical research into the benefits of medical-grade honey for skin diseases, proving that our patented formulation Honevo is an effective treatment for several conditions. Clinical studies of kanuka oil products for skin diseases are ongoing and we have a large pipeline of other products at various stages of development.

Many of HoneyLab’s research studies have been published in prestigious medical journals including the British Medical Journal Open and the European Journal of Nutrition.  Below is a list of our published research.

Publications

HoneyLab are conducting the world’s largest research programme into the medical uses of honey. We have a large pipeline of new products to test, with many trials planned and a number of trials ongoing. Below is a list of our published research.

  1. Holt S, Johnson K, Ryan J et al. New Zealand kanuka honey has high levels of MGO and antimicrobial activity. J of Alternative and Complementary Medicine. March 15 2012; 18(3): 203
  2. Holt S, Cole A. A pilot study of topical medical-grade kanuka honey for acne. Focus on Alternative and Complementary Therapies 2011 (June): 190.
  3. Holt S. Honey from old wives’ tale to medical product. Focus on Alternative and Complementary Therapies 2011 (Sept): 250-1.
  4. Holt S, Cole A. A pilot study of topical medical-grade kanuka honey for acne. Presented at World Dermatology Congress, Seoul, Korea, May 2011
  5. Holt S, Webster-Longin M, Perrin K, Baker T, Beasley R. The use of honey in the treatment of molluscum contagiosum in children. Presented at World Dermatology Congress, Seoul, Korea, May 2011
  6. Holt S. Medical honey – sticky but very effective. Contact, the journal of the Pharmacy Guild New Zealand; 2013: April
  7. Greig G, Holt S. A Pilot Study of Topical Bee Venom for Wrinkles. Presented at World Congress of Cosmetic Dermatology, Athens, Greece, May 2013
  8. Greig G, Holt S. A Pilot Study of Topical Bee Venom for Lip Plumping. Presented at World Congress of Cosmetic Dermatology, Athens, Greece, May 2013
  9. Greig G, Holt S. A Study of the Effectiveness of Anti-Wrinkle Serums. Presented at World Congress of Cosmetic Dermatology, Athens, Greece, May 2013
  10. Holt S. Medical-grade New Zealand kanuka honey as a topical treatment for acne and rosacea. Presented at World Congress of Cosmetic Dermatology, Athens, Greece, May 2013
  11. Fingleton J, Sheahan D, Cave N, et al. Topical kanuka honey for the treatment of rosacea. Focus on Alternative and Complementary Therapies 2013 (Dec): 221–222.
  12. Fingleton, James, et al. A randomised controlled trial of topical kanuka honey for the treatment of eczema. JRSM Short Reports 5.1 (2014)
  13. Fingleton J, Sheahan D, Cave N, et al. Topical kanuka honey for the treatment of psoriasis. JRSM Open Mar 2014; 5(3)
  14. Fingleton J, Tofield C, Helm C, et al. Topical kanuka honey for the treatment of nappy rash. Focus on Alternative and Complementary Therapies 2014 (March) 50–51
  15. Fingleton J, Sheahan D, Cave N, et al. Topical kanuka honey for the treatment of cold sores. Advances in Integrative Medicine 2014; 1(3) December: 119–123
  16. Holt S. Honey set for key role fighting infections. Pharmacy Today; 2014: August
  17. Fingleton J et al. A single-­blind randomised controlled trial of topical kanuka honey for the treatment of rosacea. British Medical Journal Open 2015;5 : e007651
  18. Fingleton J et al. A single-­blind randomised controlled trial of topical kanuka honey for the treatment of acne. In press
  19. Semprini A et al. A single-­blind randomised controlled trial of topical kanuka honey for the treatment of nappy rash. Focus on Alternative and Complementary Therapies 2015.
  20. Holt S et al. A topical kanuka honey formulation is an effective treatment for rosacea. Annual Meeting of the American Academy of Dermatology 2015, 21 March 2015. Poster 871
  21. Whitfield P et al. The effect of a cinnamon, chromium and magnesium formulated honey on glycaemic control, weight loss and lipid parameters in Type 2 diabetes: An open-label cross-over randomised controlled trial. European Journal of Nutrition 2015: 1-9
  22. Holt S et al. A single-blind randomised controlled trial of a topical kanuka honey formulation for the treatment of acne – oral presentation. New Zealand Dermatological Society Annual Meeting, 26th-29th August 2015, Auckland, New Zealand
  23. Holt S et al. A topical kanuka honey formulation is an effective treatment for rosacea – oral presentation. New Zealand Dermatological Society Annual Meeting, 26th-29th August 2015, Auckland, New Zealand
  24. Holt S. A New Zealand topical kanuka honey product can treat rosacea and reduce antibiotic resistance Adv Integr Med 2015; 2: 141-2
  25. Semprini A, Singer J, Shortt N, et al. Protocol for a randomised controlled trial of 90% kanuka honey versus 5% aciclovir for the treatment of herpes simplex labialis in the community setting.BMJ Open 2017;7:e017766
  26. Mane S, Singer J, Corin A,  Semprini A. Successful Treatment of Actinic Keratosis with Kanuka Honey. Case Reports in Dermatological Medicine, vol. 2018, Article ID 4628971
  27. Semprini A, Singer J, Braithwaite I, et al Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial BMJ Open 2019;9:e026201.